Overview
Milestones
Home >> Product Candidates >> Pipeline >> Sprix™ / Acute Pain
Sprix™ / Acute Pain
The Efficacy of Hospital-Strength Ketorolac in a Convenient Form
Sprix™ is a novel intranasal formulation of the potent non-steroidal anti-inflammatory drug (NSAID) ketorolac. The analgesic efficacy of ketorolac is primarily associated with the inhibition of prostaglandin synthesis via non-selective inhibition of COX-1/COX-2 enzymes.
Physicians and patients have long benefited from the potent pain-relieving properties of ketorolac as an intramuscular injection or through intravenous administration in the hospital setting. Sprix™ allows patients to receive the same benefits of hospital-strength ketorolac in a convenient form that can be used at home.
Formulated as an easy-to-use spray, Sprix™ is rapidly absorbed through the nasal mucosa, achieving peak blood levels as fast as an intramuscular injection. The pharmacokinetic properties of Sprix™ have been demonstrated in clinical trials to provide rapid relief from moderate-to-severe acute pain.
A Powerful, Non-Opioid Analgesic
Sprix™ has been extensively studied in patients experiencing acute moderate-to-severe pain. Clinical studies demonstrate that Sprix™ provides excellent pain control when used alone or when combined with opioid. In clinical studies comparing Sprix™ to placebo, Sprix™ provided significantly improved pain control and was well tolerated. When used as part of a multi-drug regimen that included opioids, Sprix™ allowed patients reduce to their opioid dose and achieve better pain relief than that provided by opioids alone.
Sprix™ Addresses Significant Unmet Needs
Oral opioids are the most commonly prescribed medicines for ambulatory patients experiencing moderate-to-severe acute pain. Yet while these powerful medicines are effective at relieving pain, they have a slow onset of action and are associated with a variety of negative side effects, including:
Dizziness, Drowsiness and Sedation
Nausea, Vomiting
Constipation
Potential for Abuse
Sprix™ is not a narcotic and has demonstrated good tolerability in clinical trials.
